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In November 2018, the FDA announced restrictions on the sale of flavored e-cigarette vape fluids. About 3.62 million middle and high school students used e-cigarettes in 2018. April 2018The FDA begins a crackdown on Juul and other e-cigs to reduce youth vaping, whereas launching an investigation into the company. 2004Stanford University grad students James Monsees and Adam Bowen come up with the concept for Ploom, an organization to fabricate tobacco vaporizers. The lung damage outbreak has been followed by a wave of states and cities ordering e-cigarette bans in their jurisdictions. Users have reported a rising record of potential e-cigarette side effects corresponding to seizures, strokes, respiratory failure and bronchiolitis obliterans organizing pneumonia, or BOOP.